RNA Details
Disease Name
myocardial infarction
Tissue
heart
RNA Symbol
Apln
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
immunofluorescence; qRT-PCR;
Target
LGR4
Pathway
APELIN SIGNALING PATHWAY
PubMed ID
Title
Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-beta-catenin signaling
Year
2016
Function
Apelin counterregulated against transverse aortic constriction (TAC)-mediated ascending aortic remodeling and angiotensin ii-induced promotion of cellular migration by blocking at1 receptor and miRNA-122 levels and preventing activation of the TGF-beta1-CTGF-NFAT5 and LRRF-beta-catenin signaling.